XXL Pump

XXL Pump is an eight-component amino acid research solution containing L-arginine, L-citrulline, L-ornithine, L-glutamine, glycine, L-lysine, branched-chain amino acids (BCAA, 2:1:1) and taurine at the per-mL concentrations listed below. Published research on these components covers arginine metabolism by arginase and nitric oxide synthase, leucine signaling through mTOR, glutamine use by immune cells, and taurine as a cellular osmolyte. The references below cover the individual components, not this combination. Research Market supplies XXL Pump with lot documentation on its certificate of analysis. It is sold strictly for laboratory research use.

Composition

• L-ARGININE 100 MG/ML
• L-CITRULINE 100MG/ML
• L-ORNITHINE 100 MG/ML
• L-GLUTAMINE 100MG/ML
• L-GLYCINE 50MG/ML
• L-LYSINE 50MG/ML
• BCAA 2:1:1 5MG/ML
• TAURINE 50MG/ML

Components

• L-Arginine: CAS 74-79-3, C₆H₁₄N₄O₂, 174.2 g/mol, PubChem CID 6322
• L-Citrulline: CAS 372-75-8, C₆H₁₃N₃O₃, 175.19 g/mol, PubChem CID 9750
• L-Ornithine: CAS 70-26-8, C₅H₁₂N₂O₂, 132.16 g/mol, PubChem CID 6262
• L-Glutamine: CAS 56-85-9, C₅H₁₀N₂O₃, 146.14 g/mol, PubChem CID 5961
• Glycine: CAS 56-40-6, C₂H₅NO₂, 75.07 g/mol, PubChem CID 750 (glycine is achiral; listed on the label as L-glycine)
• L-Lysine: CAS 56-87-1, C₆H₁₄N₂O₂, 146.19 g/mol, PubChem CID 5962 (salt form is not stated on the label)
• BCAA: L-leucine: CAS 61-90-5, C₆H₁₃NO₂, 131.17 g/mol, PubChem CID 6106
• BCAA: L-isoleucine: CAS 73-32-5, C₆H₁₃NO₂, 131.17 g/mol, PubChem CID 6306
• BCAA: L-valine: CAS 72-18-4, C₅H₁₁NO₂, 117.15 g/mol, PubChem CID 6287
• Taurine: CAS 107-35-7, C₂H₇NO₃S, 125.15 g/mol, PubChem CID 1123
• Form: Supplied in solution at the per-mL concentrations listed above

Research applications

• Arginase and NOS pathways: In macrophages, nitric oxide synthase converts arginine to nitric oxide and citrulline, while arginase hydrolyzes it to ornithine and urea, feeding polyamine and proline synthesis [1]
• BCAA and mTOR signaling: Reviewed for how leucine stimulates initiation of mRNA translation in skeletal muscle preparations through mTOR and phosphorylation of S6 kinase, 4E-BP1 and eIF4G [2]
• Glutamine and immune cells: Reviewed from in-vitro and in-vivo studies as a nutrient for lymphocyte proliferation, cytokine production and neutrophil bacterial killing [3]
• Taurine: Reviewed as an organic osmolyte and modulator of intracellular free calcium that is not incorporated into proteins yet is abundant in brain, retina and muscle tissue [4]
• Glycine: Reviewed as a precursor of creatine, glutathione, heme, purines and porphyrins, made through interorgan metabolism in kidney and liver [5]

Reference citations

1. Rath M. et al. (2014). Metabolism via arginase or nitric oxide synthase: two competing arginine pathways in macrophages. Front Immunol, 5:532. PMID 25386178 · DOI
2. Kimball S.R. et al. (2006). Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. J Nutr, 136(1 Suppl):227S–231S. PMID 16365087 · DOI
3. Cruzat V. et al. (2018). Glutamine: metabolism and immune function, supplementation and clinical translation. Nutrients, 10(11):1564. PMID 30360490 · DOI
4. Ripps H. et al. (2012). Review: taurine: a “very essential” amino acid. Mol Vis, 18:2673–2686. PMID 23170060
5. Razak M.A. et al. (2017). Multifarious beneficial effect of nonessential amino acid, glycine: a review. Oxid Med Cell Longev, 2017:1716701. PMID 28337245 · DOI

Compound data from PubChem CIDs 6322, 9750, 6262, 5961, 750, 5962, 6106, 6306, 6287, 1123. Literature summaries describe published preclinical research and are not claims about this product’s effects in humans or animals.