Hair-Skin-Nails

Hair-Skin-Nails is a research blend of nine B-complex vitamins and related compounds, led by niacinamide and thiamine HCl at 50 mg and pantothenic acid at 25 mg, with microgram amounts of biotin, folic acid and riboflavin. Each component is a precursor of an enzyme cofactor: thiamine of thiamin diphosphate, pantothenate of coenzyme A, biotin of carboxylase prosthetic groups, riboflavin of FMN and FAD, folate of one-carbon carriers, and niacinamide and niacin of NAD. The product name is a catalog label and does not describe a research outcome. Lot data are on the certificate of analysis. It is sold strictly for laboratory research use.

Composition

• Niacinamide 50mg
• Thiamine HCL 50mg
• Pantothenic Acid 25mg
• Choline 10mg
• Inositol 10mg
• Niacin 5mg
• Biotin 100mcg
• Folic Acid 100mcg
• Riboflavin 100mcg

Components

• Niacinamide: Nicotinamide (niacinamide). CAS 98-92-0; C₆H₆N₂O; 122.12 g/mol; PubChem CID 936
• Thiamine HCL: Thiamine hydrochloride. CAS 67-03-8; C₁₂H₁₈Cl₂N₄OS; 337.3 g/mol; PubChem CID 6202
• Pantothenic Acid: D-pantothenic acid (salt form not stated on the listing). CAS 79-83-4; C₉H₁₇NO₅; 219.23 g/mol; PubChem CID 6613
• Choline: Choline (cation) (salt form not stated on the listing). CAS 62-49-7; C₅H₁₄NO⁺; 104.17 g/mol; PubChem CID 305
• Inositol: Inositol. CAS 87-89-8; C₆H₁₂O₆; 180.16 g/mol; PubChem CID 892
• Niacin: Nicotinic acid (niacin). CAS 59-67-6; C₆H₅NO₂; 123.11 g/mol; PubChem CID 938
• Biotin: D-biotin. CAS 58-85-5; C₁₀H₁₆N₂O₃S; 244.31 g/mol; PubChem CID 171548
• Folic Acid: Folic acid. CAS 59-30-3; C₁₉H₁₉N₇O₆; 441.4 g/mol; PubChem CID 135398658
• Riboflavin: Riboflavin. CAS 83-88-5; C₁₇H₂₀N₄O₆; 376.4 g/mol; PubChem CID 493570
• Form: Supplied in a sealed vial, amounts as listed under Composition
• Analytical methods: Identity and purity data reported on the batch certificate of analysis

Research applications

• Thiamine: Reviewed for thiamin diphosphate-dependent enzymes, their differences between mammals and microorganisms, and the use of selective substrate and thiamin analogs in cellular and animal models [1]
• Pantothenic acid: Reviewed for the five-step synthesis of coenzyme A from pantothenate, its regulation by pantothenate kinases, and the four PanK isoforms studied through gene deletion in mice [2]
• Biotin: Reviewed as the prosthetic group of carboxylases in gluconeogenesis, fatty acid synthesis and amino acid catabolism, and for proposed roles in gene expression [3]
• Riboflavin: Reviewed for the 90 human genes encoding FMN- or FAD-dependent proteins, most of them oxidoreductases in the TCA cycle, β-oxidation and amino acid degradation [4]
• Folic acid: Reviewed for folate one-carbon metabolism and its intersection with cobalamin at methionine synthase, which uses 5-methyltetrahydrofolate as the methyl donor [5]

Reference citations

1. Bunik V.I. et al. (2013). Thiamin diphosphate-dependent enzymes: from enzymology to metabolic regulation, drug design and disease models. FEBS J, 280(24):6412–6442. PMID 24004353 · DOI
2. Dansie L.E. et al. (2014). Physiological roles of the pantothenate kinases. Biochem Soc Trans, 42(4):1033–1036. PMID 25109998 · DOI
3. León-Del-Río A. (2019). Biotin in metabolism, gene expression, and human disease. J Inherit Metab Dis, 42(4):647–654. PMID 30746739 · DOI
4. Lienhart W.D. et al. (2013). The human flavoproteome. Arch Biochem Biophys, 535(2):150–162. PMID 23500531 · DOI
5. Froese D.S. et al. (2019). Vitamin B₁₂, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis, 42(4):673–685. PMID 30693532 · DOI

Compound data from PubChem CIDs 936, 6202, 6613, 305, 892, 938, 171548, 135398658, 493570. Literature summaries describe published preclinical research and are not claims about this product’s effects in humans or animals.