Noopept (with Choline Chloride)

Noopept (with Choline Chloride) combines two compounds in one solution. Noopept (omberacetam, GVS-111) is N-phenylacetyl-L-prolylglycine ethyl ester, a dipeptide designed as an analog of piracetam; choline chloride is a salt of choline, the precursor used for acetylcholine synthesis. Noopept research covers hippocampal NGF and BDNF expression, amyloid-beta toxicity in PC12 cells and HIF-1 activity, and one rat study delivered it intranasally with forskolin. Research Market supplies this Noopept spray in a spray bottle with a lot-specific certificate of analysis. It is sold strictly for laboratory research use.

Components

• Noopept (omberacetam): CAS 157115-85-0 · C₁₇H₂₂N₂O₄ · 318.4 g/mol · PubChem CID 180496
• Choline chloride: CAS 67-48-1 · C₅H₁₄ClNO · 139.62 g/mol · PubChem CID 6209
• Form: Supplied in solution in a spray bottle
• Analytical methods: RP-HPLC for purity and mass spectrometry for identity, reported on the batch certificate of analysis

Research applications

• Neurotrophin expression: In rats, single and 28-day Noopept treatment increased NGF and BDNF mRNA in the hippocampus, and chronic treatment showed no tolerance [1]
• Amyloid-beta cell model: Pretreating PC12 cells with Noopept before Aβ25-35 exposure improved viability, lowered reactive oxygen species and intracellular calcium, and reduced tau phosphorylation at Ser396 [2]
• HIF-1 signaling: In SH-SY5Y cells, Noopept increased basal and hypoxia-mimetic-induced HIF-1 DNA-binding activity, with reporter data pointing to inhibition of HIF-1 prolyl hydroxylase [3]
• Intranasal formulation: An intranasal formulation of forskolin and Noopept was studied in PINK1 knockout rats, where it was associated with fewer motor deficits, less loss of midbrain dopamine neurons and higher brain BDNF and NGF [4]
• Choline and acetylcholine release: Microdialysis in awake rats showed that raising choline availability, by acute choline chloride or dietary choline, increased the peak and duration of atropine-evoked acetylcholine release in the hippocampus [5]

Reference citations

1. Ostrovskaya R.U. et al. (2008). Noopept stimulates the expression of NGF and BDNF in rat hippocampus. Bull Exp Biol Med, 146(3):334–337. PMID 19240853 · DOI
2. Ostrovskaya R.U. et al. (2014). Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation. J Biomed Sci, 21(1):74. PMID 25096780 · DOI
3. Zainullina L.F. et al. (2020). Cognitive enhancer Noopept activates transcription factor HIF-1. Dokl Biochem Biophys, 494(1):256–260. PMID 33119829 · DOI
4. Dagda R.K. et al. (2022). Intranasal administration of forskolin and Noopept reverses parkinsonian pathology in PINK1 knockout rats. Int J Mol Sci, 24(1):690. PMID 36614135 · DOI
5. Köppen A. et al. (1997). Acetylcholine release and choline availability in rat hippocampus: effects of exogenous choline and nicotinamide. J Pharmacol Exp Ther, 282(3):1139–1145. PMID 9316819

Compound data from PubChem CID 180496 (Noopept) and CID 6209 (choline chloride). Literature summaries describe published preclinical research and are not claims about this product’s effects in humans or animals.