Chonluten

Chonluten is sold as the synthetic tripeptide Glu-Asp-Gly (EDG), which PubChem also lists under the code T-34. Khavinson-group authors describe Chonluten as derived from bronchial epithelium. The indexed literature is small: a 2022 study of inflammatory signaling in human THP-1 monocytes, a gene expression paper on T-34, and a docking study of peptide transporters. Research Market supplies the Chonluten peptide as a lyophilized research reagent, with purity and identity data for each lot reported on its certificate of analysis. It is sold strictly for laboratory research use.

Chemical structure and identification

• Molecular formula: C₁₁H₁₇N₃O₈
• Molecular weight: 319.27 g/mol
• CAS number: 75007-24-8
• PubChem CID: 194641
• Amino acid sequence: Glu-Asp-Gly (EDG)
• Synonyms: T-34 tripeptide; L-glutamyl-L-aspartyl-glycine; H-Glu-Asp-Gly-OH
• Form: Lyophilized powder
• Analytical methods: RP-HPLC for purity and mass spectrometry for identity, reported on the batch certificate of analysis

Research applications

• Monocyte TNF response: In human THP-1 monocytes exposed to bacterial LPS, Chonluten inhibited TNF production; with four other short peptides it also reduced IL-6 and monocyte adhesion to activated endothelial cells [1]
• Antioxidant and anti-inflammatory genes: Peptide T-34 was reported to regulate mRNA expression of genes encoding antioxidant and anti-inflammatory proteins, studied in the context of gastric ulcer [2]
• Peptide transporters: In docking against LAT1, LAT2 and PEPT1, EDG ranked among the most effective transporter ligands; the authors proposed transporter inhibition as one possible basis for antitumor effects reported for EDG [3]

Reference citations

1. Avolio F. et al. (2022). Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line. Int J Mol Sci, 23(7):3607. PMID 35408963 · DOI
2. Khavinson V. et al. (2012). Peptidergic regulation of expression of genes encoding antioxidant and anti-inflammatory proteins. Bull Exp Biol Med, 152(5):615–618. PMID 22803148 · DOI
3. Khavinson V. et al. (2023). Feasibility of Transport of 26 Biologically Active Ultrashort Peptides via LAT and PEPT Family Transporters. Biomolecules, 13(3):552. PMID 36979488 · DOI

Compound data from PubChem CID 194641. Literature summaries describe published preclinical research and are not claims about this product’s effects in humans or animals.