B12 + GL1 S

B12 + GL1 S combines two research materials in one vial: vitamin B12 (cobalamin), the cobalt-containing cofactor of methionine synthase and methylmalonyl-CoA mutase, and GL1 S, a synthetic GLP-1 receptor agonist peptide analog. The two act through unrelated pathways, B12 in one-carbon and mitochondrial amino acid metabolism and GL1 S at the GLP-1 receptor, a class B G protein-coupled receptor. The literature below covers each component separately; no study of the combination is cited. Research Market supplies the B12 + GL1 S blend with identity and purity data for each lot reported on its certificate of analysis. It is sold strictly for laboratory research use.

Components

• GL1 S: GLP-1 receptor agonist peptide analog; CAS 910463-68-2; C₁₈₇H₂₉₁N₄₅O₅₉; 4114 g/mol; PubChem CID 56843331
• Vitamin B12 (cobalamin): cobalt-containing corrinoid vitamin; the cobalamin form is not specified in the product listing and is reported on the batch certificate of analysis
• Form: Lyophilized powder
• Analytical methods: RP-HPLC for purity and mass spectrometry for identity, reported on the batch certificate of analysis

Research applications

• Incretin physiology: GLP-1 is released from intestinal L-cells after meals and is rapidly inactivated by dipeptidyl peptidase IV; its reviewed actions include stimulation of insulin secretion, inhibition of glucagon secretion and slowing of gastrointestinal motility [1]
• GLP-1 receptor structure: Cryo-EM of the peptide-activated GLP-1 receptor–Gs complex showed how the peptide sits between the receptor’s N-terminal domain and transmembrane core [2]
• GLP-1 receptor circuits: Reviewed for the receptor-positive cell types and pathways that relay GLP-1 signals to islet function, appetite, inflammation and cardiovascular physiology [3]
• Cobalamin cofactor biochemistry: Cobalamin serves as adenosyl-cobalamin for mitochondrial methylmalonyl-CoA mutase and as methyl-cobalamin for methionine synthase, which remethylates homocysteine to methionine and links B12 to S-adenosylmethionine production and folate one-carbon metabolism [4]

Reference citations

1. Holst J.J. (2007). The physiology of glucagon-like peptide 1. Physiol Rev, 87(4):1409–1439. PMID 17928588 · DOI
2. Zhang Y. et al. (2017). Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein. Nature, 546(7657):248–253. PMID 28538729 · DOI
3. Drucker D.J. (2018). Mechanisms of action and therapeutic application of glucagon-like peptide-1. Cell Metab, 27(4):740–756. PMID 29617641 · DOI
4. Froese D.S. et al. (2019). Vitamin B₁₂, folate, and the methionine remethylation cycle-biochemistry, pathways, and regulation. J Inherit Metab Dis, 42(4):673–685. PMID 30693532 · DOI

Compound data from PubChem CID 56843331 (GL1 S). Literature summaries describe published preclinical research and are not claims about this product’s effects in humans or animals.